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Mexican state health minister dies after being hospitalized for COVID-19

By |2020-08-03T19:22:52+00:00August 3rd, 2020|

MONTERREY (Reuters) – The health minister of the Mexican state of Chihuahua, Dr. Jesus Grajeda, has died, Chihuahua’s governor said on Sunday, nearly two weeks after Grajeda was hospitalized with COVID-19, the respiratory disease caused by the novel coronavirus.   Read more… The post Mexican state health minister dies after being hospitalized for COVID-19 appeared [...]

Phase 3 clinical trial of investigational vaccine for COVID-19 begins

By |2020-08-03T19:22:51+00:00August 3rd, 2020|

A Phase 3 clinical trial designed to evaluate if an investigational vaccine can prevent symptomatic coronavirus disease 2019 (COVID-19) in adults has begun. The vaccine, known as mRNA-1273, was co-developed by the Cambridge, Massachusetts-based biotechnology company Moderna, Inc., and the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. [...]

Structural basis of RNA cap modification by SARS-CoV-2

By |2020-08-03T19:22:50+00:00August 3rd, 2020|

Abstract The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of COVID-19 illness, has caused millions of infections worldwide. In SARS coronaviruses, the non-structural protein 16 (nsp16), in conjunction with nsp10, methylates the 5′-end of virally encoded mRNAs to mimic cellular mRNAs, thus protecting the virus from host innate immune restriction. We report here [...]

Life course exposures continually shape antibody profiles and risk of seroconversion to influenza

By |2020-08-03T19:22:49+00:00August 3rd, 2020|

Abstract Complex exposure histories and immune mediated interactions between influenza strains contribute to the life course of human immunity to influenza. Antibody profiles can be generated by characterizing immune responses to multiple antigenically variant strains, but how these profiles vary across individuals and determine future responses is unclear. We used hemagglutination inhibition titers from 21 H3N2 [...]

Sequential immunization induces strong and broad immunity against all four dengue virus serotypes

By |2020-08-03T19:22:48+00:00August 3rd, 2020|

Abstract A major challenge in dengue vaccine development is the need to induce immunity against four dengue (DENV) serotypes. Dengvaxia®, the only licensed dengue vaccine, consists of four variant dengue antigens, one for each serotype. Three doses of immunization with the tetravalent vaccine induced only suboptimal protection against DENV1 and DENV2. Furthermore, vaccination paradoxically and [...]

Emerging diseases, livestock expansion and biodiversity loss are positively related at global scale

By |2020-08-03T19:22:46+00:00August 3rd, 2020|

Abstract Infectious diseases, biodiversity loss and livestock expansion are increasing globally, and examining patterns that link them is important for both public health and conservation. This study is a first attempt to analysis globally these patterns using General additive modelling and Structural equation modelling. A positive association between the number of infectious and parasitic diseases [...]

Colleges plan for virus testing, but strategies vary widely

By |2020-08-03T18:16:59+00:00August 3rd, 2020|

BOSTON (AP) — For students heading to Colby College in Maine this fall, coronavirus testing is expected to be a routine part of campus life. All students will be required to provide a nasal swab every other day for two weeks, and then twice a week after that. All told, the college says it will [...]

Mother’s heart stops three times during fight with E. coli infection

By |2020-08-03T18:16:58+00:00August 3rd, 2020|

“I shouldn’t have lived through it,” Katie said, reflecting on her fight with E. coli poisoning. On an early summer evening in 2016, Katie Ruffolo, a 36-year old mother of three, was battling diarrhea. She had no idea this signaled the start of an E. coli poisoning that would eventually attack her kidneys and stop her heart three [...]

Healthy headphone use: How loud and how long?

By |2020-08-03T18:16:55+00:00August 3rd, 2020|

As our society and culture become more connected through technology, the use of headphones has increased. Headphones allow people to enjoy music and have conversations from anywhere at any time. The ease of headphone use and the mobility that they afford cannot be overstated. This is particularly true currently, as our society spends more time [...]

EU passes COVID-19 relief package; Americas surge shows no slowing

By |2020-08-02T19:12:51+00:00August 2nd, 2020|

In global COVID-19 developments, European Union (EU) leaders agreed to a massive financial package to revive member country economies as surging cases in the Americas pushed the global total closer to 15 million. The world’s COVID-19 total climbed to 14,774,887 with, and 611,599 deaths reported from the disease, according to the Johns Hopkins online dashboard.   Halfpoint [...]