•    Organic emissions from PU materials in the context of human health and exposure are investigated.
•    Reported VOC and SVOC concentrations from PU insulation and household materials are reviewed.
•    OFRs are emitted in the long term and are found abundantly indoors even in buildings with no PU insulation.
•    Amines impact perceived IAQ, but it’s unclear which PU compound/s impact health individually or cumulatively.
•    A risk matrix is proposed based on implications on IAQ and further research needs.

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