Traffic-related air pollutants (TRAP-PM) promote neuronal amyloidogenesis through oxidative damage to lipid rafts
• Exposure to traffic-related air pollutants (TRAP) of nano-particle size (nPM) increases pro-amyloidogenic processing of APP.
• TRAP increases the oxidative damage to lipid rafts, both in vivo and in vitro, as shown by increased 4-HNE levels.
• In vitro, antioxidant N-acetyl-cysteine (NAC) attenuated nPM-induced oxidative damage to lipid rafts and APP/Abeta levels.
• Lipid raft alterations of APP processing represents a novel target of air pollution.
Traffic-related air pollution particulate matter (TRAP-PM) is associated with increased risk of Alzheimer Disease (AD). Rodent models respond to nano-sized TRAP-PM (nPM) with increased production of amyloid Aβ peptides, concurrently with oxidative damage.