Key Points

Question Is there an association between COVID-19 vaccination status and mortality among critically ill patients who require invasive mechanical ventilation owing to acute respiratory distress syndrome related to COVID-19?

Findings In this multicenter cohort study comprising 265 patients, after adjustment for confounders, full vaccination status compared with controls was associated with lower mortality among critically ill patients who required invasive mechanical ventilation owing to COVID-19–related acute respiratory distress syndrome.

Meaning The findings of this study suggest that full vaccination may be associated with lower mortality among patients who were intubated owing to COVID-19–related acute respiratory distress syndrome; therefore, total benefits of vaccination against COVID-19 may exceed those estimated from the prevention of invasive mechanical ventilation alone.

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