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Maternal mortality linked to COVID-19 in Latin America: Results from a multi-country collaborative database of 447 deaths

This study aimed to describe the clinical characteristics of maternal deaths associated with COVID-19 registered in a collaborative Latin-American multi-country database.


Population genomics confirms acquisition of drug-resistant Aspergillus fumigatus infection by humans from the environment

Infections caused by the fungal pathogen Aspergillus fumigatus are increasingly resistant to first-line azole antifungal drugs. However, despite its clinical importance, little is known about how susceptible patients acquire infection from drug-resistant genotypes in the environment.


Researchers find natural mechanism to sensitize cancer to immunotherapy

Researchers at the University of Michigan Rogel Cancer Center found that a cytokine, a category of protein that acts as messengers in the body, and a fatty acid can work together to trigger a type of cell death previously defined by studies with synthetic molecules.


Much of the response to Covid-19 to date has been reactionary. Travel restrictions were implemented after a new variant had already breached the country. The use of higher-quality masks was recommended months after the emergence of increasingly more infectious variants — Alpha, Delta, then Omicron — and well after shortages had subsided. The need to ramp up the availability of rapid antigen tests was recognized during the sixth wave of Covid and amid the winter holidays.


Large-scale plasma proteomics can reveal distinct endotypes in chronic obstructive pulmonary disease and severe asthma

Chronic airway diseases including chronic obstructive pulmonary disease (COPD) and asthma are heterogenous in nature and endotypes within are underpinned by complex biology. This study aimed to investigate the utility of proteomic profiling of plasma combined with bioinformatic mining, and to define molecular endotypes and expand our knowledge of the underlying biology in chronic respiratory diseases.


Additional antibodies may protect against COVID

When we talk about antibodies against COVID-19, we tend to mean the so-called neutralizing antibodies, that offer protection by blocking the virus from invading our cells. Now, a new study from Lund University in Sweden has revealed that non-neutralizing antibodies may also be important in providing protection against COVID.


Cannabinoids Block Cellular Entry of SARS-CoV-2 and the Emerging Variants

As a complement to vaccines, small-molecule therapeutic agents are needed to treat or prevent infections by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and its variants, which cause COVID-19.


Factors determining the diffusion of COVID-19 and suggested strategy to prevent future accelerated viral infectivity similar to COVID

This study has two goals. The first is to explain the geo-environmental determinants of the accelerated diffusion of COVID-19 that is generating a high level of deaths. The second is to suggest a strategy to cope with future epidemic threats similar to COVID-19 having an accelerated viral infectivity in society. Using data on sample of N = 55 Italian province capitals, and data of infected individuals at as of April 7th, 2020, results reveal that the accelerate and vast diffusion of COVID-19 in North Italy has a high association with air pollution of cities measured with days exceeding the limits set for PM10 (particulate matter 10 μm or less in diameter) or ozone.


The hidden air pollution inside your workplace

Chris Birch used to dread late afternoon meetings at the old Stretford office of Hilson Moran, a Manchester engineering consultancy. “You’d be sat in a meeting for three hours, feeling slightly headachy, tired and stuffy,” says Birch, the company’s head of sustainability. Outdoors, when very polluted, you can see and taste and smell it. But indoors, you often can’t detect what’s there - Noakes


Scientists may need to rethink how genomics impacts risk for OCD

Both rare and commonly observed differences in the DNA letters strung along a person's chromosomes can explain about a third of the risk for being diagnosed with obsessive-compulsive disorder (OCD), according to a new study led by scientists at the Icahn School of Medicine at Mount Sinai.


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