The development of treatment with antibodies directed towards HER2 positive breast cancer trastuzumab and pertuzumab, has proven better possibility to treatment and cure of this cancer type if these antibodies are combined with chemotherapy, often taxaner. Preoperative (neoadjuvant) treatment with this combination gives a high proportion of cases with complete response. Trastuzumab emtansin (T-DM1) consists of trastuzumab (T) and the cytotoxic substance emtansin (DM1) which in clinical trials has shown good effect and comparably low toxicity.

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