Effects of early life exposure to home environmental factors on childhood allergic rhinitis: Modifications by outdoor air pollution and temperature

Highlights

•    Pre-birth home air pollution and allergen were related with allergic rhinitis (AR).

•    Post-birth home mold/dampness and plant allergens exposure increased AR risk.

•    Pre-birth is a critical window for AR risk of home environmental exposure.

•    Traffic-related air pollution increased AR risk of indoor environmental exposure.

•    Low and high temperature interacted with indoor environment on AR in early life.

Abstract

Background

There is growing evidence that allergic rhinitis (AR) is associated with indoor environmental factors, but their role in childhood AR during early life remains unclear.

Objective

To investigate the association of preconceptional, prenatal, early postnatal, and current exposure to home environmental factors with childhood AR, and to further explore whether this association can be interacted by outdoor air pollution and temperature.

Methods