A Florida infant and a child from New Hampshire represent the latest reported pediatric monkeypox infections, and both cases highlight the role that household contacts and surface contamination could play in monkeypox exposure.

Today in Morbidity and Mortality Weekly Report, authors describe a Florida infant who contracted monkeypox and presented to the emergency room with a distinct rash that developed into cellulitis. The infant—who had four caregivers—was administered intravenous antibiotics for secondary bacterial cellulitis associated with having scratched a lesion on the arm.

Ten days after rash onset, the infant tested positive for monkeypox. The baby never developed a fever and his or her condition did not worsen. Eye drops were administered, however, as some rash pustules developed on the eyelid.