Persons with cancer have high risks of COVID-19 infection and death, especially in 2020, when vaccines were not available.¹ Cancer care was disrupted, particularly among patients with socioeconomic disadvantages.²^,3 Although research using data from electronic health records and medical claims evaluated the adverse effects of the pandemic in cancer care and outcomes, there are limited data on the excess death burden associated with the combination of COVID-19 and cancer during the first year of the pandemic. Using 2020 mortality data in the US, this cross-sectional study quantified deaths caused by both cancer and COVID-19 and identified the most vulnerable populations.

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