Identification of mcr-1-positive multidrug-resistant Escherichia coli isolates from clinical samples in Shanghai, China

Highlights

•    3.9% of fecal samples from clinical settings in Shanghai were mcr-1-positive E. coli strains.

•    All mcr-1 was detected in 4 types of E. coli, including aEPEC, EPEC, ETEC, and EAEC.

•    Half of the strains carrying quinolone resistance- or β-lactam resistance-related genes were multidrug-resistant.

•    IncX4 was the predominant type in mcr-1-positive E. coli.
 

Abstract

Objectives

: Since the gene encoding mobilized colistin resistance (mcr-1) was first reported in China in 2015, it has been reported in various Enterobacteriaceae worldwide. Escherichia coli, one of the main pathogens causing diarrhea, is the most prevalent, clinically identified species carrying mcr-1. This study aimed to investigate the epidemiologic and genomic characteristics of mcr-1 in E. coli from patients in Shanghai.

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