"AML cells are highly dependent on the RNF5 protein," says Ze'ev Ronai Ph.D., director of the NCI-designated Cancer Center at Sanford Burnham Prebys and senior author of the paper. "If we inhibit it, AML cells don't survive. We can also use RNF5 levels to stratify patients for specific treatments. For example, if AML patients have low levels of RNF5 or RBBP4, they respond better to HDAC inhibitors, which are targeted treatments already used in the clinic."

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