Scientists at Scripps Research, IAVI, the Ragon Institute and Moderna, Inc., have come together to make critical advances in developing an effective vaccine against human immunodeficiency virus (HIV).

The findings were published on September 29, 2022, in Immunity in two individual papers. The research describes the first steps in a vaccine approach that aims to prompt the creation of broadly neutralizing antibodies (bnAbs)—antibodies that are broad enough to fight and protect against many different variants of a virus. By identifying the most promising bnAbs and the human genes needed to make them—as well as designing protein and mRNA vaccine candidates to begin bnAb creation and verifying the vaccine candidates—the team is paving the way to create an effective HIV vaccine.

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