In recent months, mounting evidence has suggested the standard two-dose regimen for mRNA COVID-19 vaccines does not offer as much protection for immunocompromised people as it does for the general population.

Despite making up less than 3% of the U.S. adult population, immunocompromised people account for nearly 45% of breakthrough COVID-19 infections requiring hospitalization.

Given the available data, the Centers for Disease Control and Prevention has recommended that people who are moderately to severely immunocompromised receive a third dose of the mRNA vaccine. The FDA authorized the additional dose August 12.

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