The purpose of this report is to provide timely updates regarding CDC’s ongoing response to the monkeypox (MPX) outbreak in the United States, and to share preliminary results of new analyses that can improve understanding of the outbreak and inform further scientific inquiry. This report is intended for a technical audience; each report features a combination of standing topics and the results of special analyses. Additional information about the status of the outbreak, guidance, and information for the general public can be accessed at CDC’s monkeypox outbreak response page.

On May 17, 2022, the United States confirmed the first monkeypox case in Massachusetts. As of August 26, there are 17,432 cases in all 50 states, the District of Columbia, and Puerto Rico (Figure 1). These case counts include those who tested positive for either monkeypox virus or orthopoxvirus as described in the 2022 Monkeypox Response case definition. An epidemiological curve of all monkeypox cases reported to CDC through August 26, 2022, is depicted in Figure 2. A 14-day rolling average has been included in the epidemiological curve to help account for fluctuations in daily reporting. Additionally, a cumulative case count curve of monkeypox cases by report date is provided in Figure 3. Case data are voluntarily reported by states.

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