Highlights

• Vaccination against SARS-CoV-2 remains an important measure to prevent serious infection.
• Misinformation and doubts regarding the vaccines should be properly addressed.
• Studies published so far report no association between covid19 vaccines and fertility.
• Future studies should focus on longer follow up time, systematic investigation, and representativeness.

Abstract

Background

Despite literature’s evidence about COVID-19 vaccines safety, concerns have arisen regarding adverse events, including the possible impact on fertility, accentuated by misinformation and anti-vaccine campaigns. The present study aims to answer the question: Is there any impact of COVID-19 vaccines on the fertility of men and women of reproductive age?

Methods

PubMed, Scopus, Web of Science, Cochrane and Embase databases were searched for eligible studies until June 8th, 2022. The search was restricted to articles regarding humans, published in any language, without additional restrictions. Studies’ quality was assessed by the Newcastle-Ottawa and the Before and After Quality Assessment scales for cohort and pre-post studies, respectively. Random-effect meta-analyses were performed for parameters considered in ≥2 studies, calculating means, p-values and 95% Confidence Intervals (CIs).

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