Researchers are hunting through waste water for heavily mutated SARS-CoV-2 variants that could be the next Omicron.

Virologist Dave O’Connor admits that he was getting desperate when he started asking dog owners for poo samples.

For much of 2022, O’Connor, at the University of Wisconsin–Madison, and his colleagues have been tracking a heavily mutated variant of SARS-CoV-2, the virus that causes COVID-19. Early this year, they discovered the variant in Wisconsin waste water drawn from more than 100,000 people.

Following the sewer system to ever-smaller watersheds, they narrowed the variant’s source to one particular area. O’Connor and his team thought that the variant might be circulating in dogs, in part because they found canine genetic material in the same wastewater samples. So they headed to the local dog park. “It was the strangest request you’re ever going to hear: ‘Hey, we’re scientists. Can we just have that bag of dog poop that you’re throwing away?’”

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