Treatment outcomes for multidrug- and rifampicin-resistant tuberculosis in Central and West Africa: a systematic review and meta-analysis
Highlights
Abstract
Objectives
We aimed to investigate published data on treatment outcomes of MDR/RR-TB in Central and West Africa as these, to our knowledge, are sparsely available.Methods
Systematic review and meta-analysisResults
14 studies were included representing 4268 individuals in 14 of the 26 countries. Using a random-effects model meta-analysis, we observed a pooled success rate of 80.8% [95%CI 56.0-93.3] for the Central African subgroup and 69.2% [95%CI 56.3-79.7] for the West African subgroup [p=0.0522]. The overall treatment success for all studies was 74.6% [95%CI 65.0-82.2]. We found high heterogeneity among included studies [I2=96.1%]. The estimated proportion of successfully treated MDR/RR-TB individuals was considerably higher than the global estimate provided by the WHO (59%) reaching the 2015 WHO target of at least 75% treatment success for MDR-TB.Conclusions
The use of shorter treatment regimens and the standardized treatment conditions including DOT in these studies could have contributed to a high treatment success. Yet, the available literature was not fully representative of the regions, possibly highlighting the sparse resources in many of these countries.
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