The cross-sectional analysis of 51 US NICUs participating in the Pediatric Health Information System found that, on the day of the study (Oct 25, 2017), among 2,813 hospitalized newborns, 656 (23%) received at least one antibiotic, and 345 (12%) received more than one antibiotic.

Across all 51 NICUs, the prevalence of antibiotic use ranged from 0% to 59%. Ampicillin (25%), gentamicin (19%), vancomycin (10%), and cefazolin (7%) were the most prescribed antibiotics.

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