Alzheimer’s disease is the leading cause of dementia. It progressively worsens multiple aspects of health over time, from short-term memory loss to behavioral changes to loss of bodily functions. The actual cause of Alzheimer’s is currently unknown. One widely-accepted hypothesis proposes that Alzheimer’s is caused by the accumulation of misfolded proteins in the brain. Unfortunately, many drugs targeting misfolded proteins perform poorly in clinical trials, hinting that this hypothesis might be wrong. Misfolded proteins might be another side effect, not the cause.

 

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