How is Clostridioides difficile epidemiology changing? What risk factors are associated with community-acquired C. diff (CA-CDI)? How has molecular epidemiology improved our understanding of Cdiff transmission? What are the potential novel sources of Cdiff?

Investigators with Duke University Medical Center certainly asked the right questions in “Novel and Emerging Sources of Clostridioides difficile Infection,” a new study published December 19 in PLOS Pathogens.
The global answer is that infection preventionists and other infection control professionals will have their work cut out for them in the coming year. They’ll have to contend with diversity among C. diff isolates, mounting evidence that it’s often transmitted outside the hospital, and that those multiple sources of infection will put current infection control processes to the test. Coming up with the best approach will take lots of exposure-related data, coupled with whole genome sequencing.

Credit: Jennifer Oosthuizen CDC

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