In the Press

A retrospective cohort study of idiopathic diaphragmatic palsy: a diagnostic triad, natural history and prognosis

Tests of respiratory muscle strength are valuable in the diagnostic workup of patients with unexplained dyspnoea. A triad of 1) orthopnoea with 2) normal lung imaging and 3) MEP/MIP and/or MEP/SNIP ratios ≥2.7 points towards isolated diaphragmatic palsy.


Antibody-drug conjugate shows impressive activity in patients with non-small cell lung cancer with mutation in HER2 gene

More than half of patients with non-small cell lung cancer (NSCLC) bearing a mutation in the HER2 gene had their tumors stop growing or shrink for an extended time after treatment with a drug that hitches a chemotherapy agent to a highly targeted antibody, an international clinical trial led by investigators at Dana-Farber Cancer Institute has found.


Impairment of hypoxic pulmonary vasoconstriction in acute respiratory distress syndrome

Our review provides a detailed overview of mechanisms underlying the V/Q mismatch in ARDS and its contribution to hypoxaemia, and could help to assess the relevance of treatment options currently being discussed for treatment of ARDS in COVID-19 patients


52 people fall ill after unsafe water hits public drink supplies

Unsafe water entered the public drinking water supply at two water treatment plants last month, the Environmental Protection Agency has confirmed.


Glanders outbreak in Nepal kills 16 equines

An outbreak of the deadly disease Glanders in Nepal has killed 16 equines, with the illegal movement of animals cited as the cause by the World Organisation for Animal Health (OIE).


Novel bile acid biosynthetic pathways are enriched in the microbiome of centenarians

Centenarians have a decreased susceptibility to ageing-associated illnesses, chronic inflammation and infectious diseases1,2,3.


Phase 3 trial shows safety, high efficacy of typhoid conjugate vaccine

A phase 3 clinical trial conducted in Malawi has found that a single dose of typhoid conjugate vaccine (TCV) is safe and more than 80% effective at protecting children against typhoid fever, an international team of researchers reported yesterday in the New England Journal of Medicine.


First-of-its-kind study: Use of computer-assisted colonoscopies reduces rate of missed lesions

Colorectal cancer is the third most diagnosed cancer and the second leading cause of cancer deaths in the United States. Regular screening for pre-cancerous lesions called adenomas has been shown to reduce the risk of death from colon cancer by more than 60 percent. However, adenoma detection rates and, conversely, adenoma miss rates vary greatly across physicians, with miss rates ranging from six percent to 41 percent.


Researchers use unique imaging technology to map cells tied to inflammatory bowel disease

New "maps" of hundreds of thousands of cells related to inflammatory bowel disease shed greater light on their effects on intestinal tissues through a newly utilized imaging technique called imaging mass cytometry.


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