In the Press

Autoimmunity to Annexin A2 predicts mortality among hospitalised COVID-19 patients

Levels of anti-Annexin A2 antibodies at admission strongly predicted mortality among hospitalised COVID-19 patients.

World Health Organization advisers urge global effort to regulate genome editing

On Monday, a World Health Organization advisory committee called on the world’s largest public health authority to stand by the 2019 statement of its director-general urging a halt to any experiments that might lead to the births of more gene-edited humans.

Replication Dynamics for Six Gram-Negative Bacterial Species during Bloodstream Infection

Bloodstream infections (BSI) are a major public health burden due to high mortality rates and the cost of treatment.

Effectiveness of a Multicomponent Intervention to Reduce Multidrug-Resistant Organisms in Nursing Homes A Cluster Randomized Clinical Trial

Question What is the effect of a multicomponent infection prevention intervention on multidrug-resistant organisms in nursing homes?

Progressive Increase in Virulence of Novel SARS-CoV-2 Variants in Ontario, Canada

The period from February to June 2021 was one during which initial wild-type SARS-CoV-2 strains were supplanted in Ontario, Canada, first by variants of concern (VOC) with the N501Y mutation (Alpha/B1.1.17, Beta/B.1.351 and Gamma/P.1 variants), and then by the Delta/B.1.617 variant.

Gene therapy for aromatic L-amino acid decarboxylase deficiency by MR-guided direct delivery of AAV2-AADC to midbrain dopaminergic neurons

Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare genetic disorder characterized by deficient synthesis of dopamine and serotonin.

Difference in mortality among individuals admitted to hospital with COVID-19 during the first and second waves in South Africa: a cohort study

The first wave of COVID-19 in South Africa peaked in July, 2020, and a larger second wave peaked in January, 2021, in which the SARS-CoV-2 501Y.V2 (Beta) lineage predominated. We aimed to compare in-hospital mortality and other patient characteristics between the first and second waves.

Studies elucidate poorly understood long COVID

Three new studies detail "long-haul" COVID-19, one finding 203 symptoms involving 10 organ systems, another showing that more than five coronavirus symptoms in the first week of infection portends a long disease course, and one finding few long-haul–like symptoms in children.

HIV infection drives interferon signaling within intestinal SARS-CoV-2 target cells

Severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) infects epithelial cells of the human gastrointestinal (GI) tract and causes related symptoms.

Estimated Acute Effects of Ambient Ozone and Nitrogen Dioxide on Mortality in the Pearl River Delta of Southern China

Background and objectives: Epidemiologic studies have attributed adverse health effects to air pollution; however, controversy remains regarding the relationship between ambient oxidants [ozone (O3) and nitrogen dioxide (NO2)] and mortality, especially in Asia.