In the Press

Nonlytic cellular release of hepatitis A virus requires dual capsid recruitment of the ESCRT-associated Bro1 domain proteins HD-PTP and ALIX

Although picornaviruses are conventionally considered ‘nonenveloped’, members of multiple picornaviral genera are released nonlytically from infected cells in extracellular vesicles.


Regular physical activity tied to lower risk of COVID, poor outcomes

At least 150 minutes (2.5 hours) of moderate physical activity—or 75 minutes (1.2 hours) of vigorous exercise—weekly was linked to a lower risk of COVID-19 infection, hospitalization, severe illness, and death during periods dominated by the Beta and Delta variants, according to a systematic review and meta-analysis published yesterday in the British Journal of Sports Medicine.


Food Allergies Can Be Reversed by Targeting the Microbiome

Summary: Researchers developed polymeric micelles of butyrate, a bacterial compound made by healthy a microbiome, that is effective against peanut allergies in mice.


Transmission of SARS-CoV-2 by inhalation of respiratory aerosol in the Skagit Valley Chorale superspreading event

During the 2020 COVID-19 pandemic, an outbreak occurred following attendance of a symptomatic index case at a weekly rehearsal on 10 March of the Skagit Valley Chorale (SVC).


Physical activity and risk of infection, severity and mortality of COVID-19: a systematic review and non-linear dose–response meta-analysis of data from 1 853 610 adults

Objective To quantify the association between physical activity and risk of SARS-CoV-2 infection, COVID-19-associated hospitalisation, severe illness and death due to COVID-19 in adults.


Trials for monkeypox antiviral, fractional vaccine dosing launch

As countries contend with more and more monkeypox cases, UK and US officials have announced the launch of clinical trials to gauge how effective the antiviral drug tecovirimat, known as Tpoxx, is for treating the disease, and to establish how protective intradermal fractional doses of the Jynneos vaccine are against monkeypox. In addition, Brazil has confirmed 77 cases of the poxvirus in children, and Spain becomes the latest country to initiate fractional vaccine dosing.


Glacier ice archives nearly 15,000-year-old microbes and phages

Glacier ice archives information, including microbiology, that helps reveal paleoclimate histories and predict future climate change. Though glacier-ice microbes are studied using culture or amplicon approaches, more challenging metagenomic approaches, which provide access to functional, genome-resolved information and viruses, are under-utilized, partly due to low biomass and potential contamination.


Antibiotics Drive Expansion of Rare Pathogens in a Chronic Infection Microbiome Model

Chronic (long-lasting) infections are globally a major and rising cause of morbidity and mortality. Unlike typical acute infections, chronic infections are ecologically diverse, characterized by the presence of a polymicrobial mix of opportunistic pathogens and human-associated commensals.


Study: Incubation times of SARS-CoV-2 variants fell over time

As the dominant circulating strain of SARS-CoV-2 evolved from Alpha to Omicron, the incubation period from infection to symptoms or first positive COVID-19 test result gradually decreased, from 5 to 3.4 days, according to a systematic review and meta-analysis published today in JAMA Network Open.


New Ebola case in DRC likely linked to earlier outbreak

Over the weekend, the World Health Organization (WHO) African regional office reported a suspected Ebola case in the Democratic Republic of the Congo's (DRC's) North Kivu province, and today an official from the country's national lab confirmed the finding, according to media reports.


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